This is a great question and the short answer is, it depends on where it’s going and who’s giving it. Most physicians who are experienced with replacing lost volume in the face are going to have their favorites of course, but different fillers have different attributes, and at least a small armamentarium is necessary to address the needs of different patients and different parts of the face in an individual.
Any injectable must be FDA-approved and must have been ordered directly from the manufacturer to avoid the disasters of “bootleg” products. Beyond that, the particular filler (or fillers) chosen is tailored to the individual’s needs. Then if the physician is skilled, ethical and has an intuitive understanding of facial harmony and proportion, the outcome should look entirely natural.